RESUMO
ABSTRACT Objective: We evaluated the protective effect of postpartum resilience (measured before the pandemic onset) on the prevalence of moderate to severe anxiety symptoms during the coronavirus disease (COVID-19) pandemic. Methods: The sample included 589 mothers from a longitudinal study in southern Brazil. Three months after delivery we assessed maternal resilience through the Resilience Scale (RS). The Generalized Anxiety Disorders 7-item (GAD-7) was used to assess anxiety symptoms during the COVID-19 pandemic. Results: The prevalence of severe to moderate anxiety symptoms in this sample was 28.4% (95% CI: 25.0; 32.0). Resilience showed to be a protective factor against moderate to severe anxiety symptoms during the pandemic (OR: 0.98; p<0.001). Conclusions: The results showed that postpartum resilience is a factor associated with lower odds of a more intense manifestation of anxiety during pandemic periods. Thus, strengthening resilience by reinforcing appropriate coping strategies can prevent mental health problems.
RESUMO Objetivo: Avaliou-se o efeito protetor da resiliência pós-parto (medida antes do início da pandemia) sobre a prevalência de sintomas de ansiedade moderados a graves durante a pandemia da doença por coronavírus (COVID-19). Métodos: A amostra incluiu 589 mães de um estudo longitudinal do Sul do Brasil. Três meses após o parto, avaliou-se a resiliência materna por meio da Resilience Scale (RS). O Generalized Anxiety Disorders 7-item (GAD-7) foi usado para medir os sintomas de ansiedade durante a pandemia de COVID-19. Resultados: A prevalência de sintomas de ansiedade moderados a graves nessa amostra foi de 28,4% (IC 95%: 25,0-32,0). A resiliência mostrou-se um fator protetor para os sintomas de ansiedade moderados a graves durante a pandemia (RC: 0,98; p<0,001). Conclusões: Os resultados revelaram que a resiliência pós-parto é um fator associado a menor chance de uma manifestação mais intensa da ansiedade durante os períodos pandêmicos. Dessa forma, fortalecer a resiliência, reforçando estratégias de enfrentamento apropriadas, pode prevenir problemas de saúde mental.
RESUMO
Abstract The present study aimed to evaluate the anti-inflammatory potential of a Lycium barbarum (L. barbarum) fruit extract in Wistar rats submitted to a palatable diet presenting systemic inflammation induced by lipopolysaccharides (LPS). Forty-two Wistar female rats (Rattus Novergicus) were used with 60 days old. The animals were feed for 60 days and divided in six groups (n=7): standard diet+water; standard diet+L. barbarum; palatable diet+water; palatable diet+L. barbarum; standard diet+water+LPS; standard diet+L. barbarum+LPS. A significant difference was shown between the analyzed groups concerning C-reactive protein, with the standard diet+water+LPS group presenting the highest inflammatory response in comparison to the other groups. Decreased inflammatory response was observed in the group administered a palatable diet along with the fruit extract when compared to the group that received only a palatable diet. Significant decrease in glutamic-oxaloacetic transaminase activity was observed in the standard diet+L. barbarum+LPS group compared to the standard diet+water group, as well as in the palatable diet+L. barbarum group compared to the palatable diet+water group. A significant increase in creatinine in the standard diet+water+LPS group was observed in according to the L. barbarum administration groups. The gene expression of the inflammatory markers genes in the liver showed a significant increase in TNF-α and IL-6 genes in the group treated with standard diet+L. barbarum+LPS when compared to the standard diet+LPS group. Thus, the administered L. barbarum extract displays the potential to reduce inflammatory responses induced by LPS and a palatable diet.
